An unannotated coding reserve in bacterial genomes? Event as iCalendar

(Biodiversity and Biosecurity, Biological Sciences, Chemical Sciences, Seminars)

11 May 2017

2 - 3pm

Venue: Mac 2, Biology Building

Location: 5 Symonds Street, City Campus

Host: School of Biological Sciences

Cost: Free - all welcome

Contact info: Dr Sarah Knight

Contact email:

An unannotated coding reserve in bacterial genomes?

Dr Zachery Ardern, post-doctoral researcher in bacterial genomics, Technical University of Munich, Germany

Recent work in microbial genomics has discovered multi-faceted, previously unknown complexity in bacterial genomes, including hundreds of small RNAs and unannotated small proteins and pervasive transcription antisense to protein-coding genes.

There is also increasing evidence of a large unannotated coding reserve in many bacterial genomes consisting of hundreds of highly gene-like sequences in a typical genome.

Much of this coding reserve is found overlapping currently annotated genes. Coding overlap is a phenomenon closely investigated in viruses, but seldom considered significant in bacteria.

The evidence for genes or coding reserve with non-trivial overlaps with annotated genes includes strand-specific knock-out experiments, ribosomal profiling, and evolutionary conservation. 

Please get in touch with Dr Sarah Knight ( if you would like to join Dr Ardern for lunch before the seminar, or you would like to arrange a meeting.