Modular route for vaccine design and manufacturing Event as iCalendar

(Biodiversity and Biosecurity, Biological Sciences, Seminars)

15 September 2017

1 - 2pm

Venue: Building 106, BLT 204

Location: 5 Symonds Street, Auckland

Host: School of Biological Sciences

Cost: Free

Contact info: Laura Domigan

Contact email: l.domigan@auckland.ac.nz

Associate Professor Linda Lua
Associate Professor Linda Lua, Director of Protein Expression Facility, University of Queensland, Australia

Vaccines have effectively protected the population against many infectious pathogens. Over the last decade, sudden disease outbreaks of influenza, MERS, Ebola and Zika have been experienced.

The unpredictability and spread of disease are concerning. It highlights the limitations of the current vaccine manufacturing methods to respond to immediate threats. Associate Professor Linda Lua presents an engineered, virus-like particle (VLP) platform for the modularisation of immunogenic antigens.

Modular VLPs and capsomeres (pentameric subunits) presenting peptide epitope or protein domain have demonstrated immunogenicity and efficacy against diseases such as influenza and rotavirus. Computational biology simulation aids in the design of conformational epitope presentation to prevent steric hindrance on the surface of these modular architectures. The robustness and flexibility of the platform are further enhanced by a simplified production process, which uses a microbial cell factory and a non-chromatographic purification strategy.

Process simulation has predicted a manufacturing capability of millions of vaccine doses within a week, highlighting the modular platform as a promising approach to deliver modern vaccines for rapid response.