Viewing diseases though translational lens Event as iCalendar

(Biodiversity and Biosecurity, Biological Sciences, Seminars)

01 December 2017

12 - 1pm

Venue: MAC 1, Biology Building

Location: 5 Symonds Street, Auckland

Contact info: Associate Professor Peter Wills

Contact email: p.wills@auckland.ac.nz

Professor Dr Zoya Ignatova

 

Several human pathologies are traditionally viewed as a mutation-driven failure of the function of one or many proteins.

Protein synthesis in the cell is a multi-layered process including transcription of the genetic information within DNA into messenger RNA, translation of the nucleotide code into peptide code, and folding to mature functional protein that conveys a physiological activity.

Translation has been seen as an obligatory intermediate with little to no effect on the final function of a protein. Using various high-resolution methods to measure translation fidelity and speed Professor Dr Zoya Ignatova will show that translation plays a critical role in modulating disease severity. Moreover, some mutations counteract the devastating effect of a main mutation by fine-tuning translational velocity.

Dr Zoya Ignatova is a Visiting Humbolt Fellow and is hosted by Associate Professor Peter Wills, Department of Physics. To arrange a meeting with Dr Ignatova, please contact AP Wills: p.wills@auckland.ac.nz