MicroED: Conception, practice and future opportunities Event as iCalendar

07 December 2018

1 - 2pm

Venue: Mac 1 Biology Building

Location: 5 Symonds St

Host: SBS

Contact info: Assoc Prof Christopher Squire

Contact email: c.squire@auckland.ac.nz

Professor Tamir Gonen
Professor Tamir Gonen

Speaker: Professor Tamir Gonen, David Geffen Medical School, University of California, Los Angeles, USA

In 2013 Professor Tamir Gonen and colleagues unveiled the method MicroED, electron diffraction of microscopic crystals, and demonstrated that it is feasible to determine high-resolution protein structures by electron crystallography of three-dimensional crystals in an electron cryo-microscope (CryoEM). The CryoEM is used in diffraction mode for structural analysis of proteins of interest using crystals that are a billion times smaller in volume than what is used for x-ray crystallography.

In this seminar Professor Gonen will describe the basics of this method, from concept to data collection, analysis and structure determination, and illustrate how samples that were previously unattainable can now be studied by MicroED. He will conclude by highlighting how this new method is helping researchers to understand major brain diseases like Parkinson’s disease; discover and design new drugs; shed new light on chemical synthesis; and show an unprecedented level of detail with sub atomic resolutions.