Rewriting the mammalian cell ‘source code’ Event as iCalendar

04 March 2019

1 - 2pm

Venue: Mac 1 Biology Building

Location: 5 Symonds St

Host: SBS

Contact info: Hilary (Billy) Sheppard

Contact email: h.sheppard@auckland.ac.nz

Associate Professor Tudor Fulga
Associate Professor Tudor Fulga

Speaker: Associate Professor Tudor Fulga, Radcliffe Department of Medicine, Medical Sciences Division, University of Oxford, UK


The ability to manipulate gene expression is of great importance to basic research and therapeutic intervention. Within the past few years, CRISPR/Cas9 leaped from a basic experimental tool to a game-changing platform for biomedical research with far reaching implications in curative, regenerative and preventive medicine.

Most notably, the astonishing wave of innovations in this field has radically expanded the scope of ex vivo somatic and stem cell engineering from simple viral transgene expression to site-specific knock-ins, controlled gene disruption, and direct correction of disease-causing mutations. These ground-breaking studies have not only redefined the promise of cell-based interventions for multiple disease indications, but have also set the stage for the implementation of more sophisticated regulatory programs aiming to modulate cellular behaviour and function.

By merging the core principles of cell/genome engineering and synthetic biology, Associate Professor Tudor Fulga and colleagues currently endeavour to create artificial signalling pathways and gene networks responsive to exogenous cues and/or endogenous metabolites. Ultimately, their aim is to establish new experimental frameworks for programmed regulation and correction of gene expression, and apply these systems to develop cell-based therapies for acquired or inherited human diseases.

For more information please contact Hilary (Billy) Sheppard.