GPCRomics: Identification of novel G protein-coupled receptors (GPCRs) in health and disease Event as iCalendar

(Seminars, Biological Sciences)

02 March 2018

1 - 2pm

Venue: Mac 1

Location: 5 Symonds Street, Auckland Central

Host: SBS

Contact info: Professor Debbie Hay

Contact email: dl.hay@auckland.ac.nz

Professor Paul Insel, Department of Pharmacology, University of California San Diego, USA
Professor Paul Insel, Department of Pharmacology, University of California San Diego, USA


Our speaker
: Professor Paul Insel, Department of Pharmacology, University of California San Diego, USA.


G protein-coupled receptors (GPCRs) are the largest family of signalling receptors and the largest group of targets of approved drugs. However, many aspects of GPCR biology remain poorly defined. For example, the physiologic agonists are unknown and functional roles are ill-defined for approximately a third of the GPCRs (‘orphan GPCRs’).

In this seminar, Professor Paul Insel will review key aspects of GPCR biology that are known and unknown and will focus on GPCRomics: defining GPCR expression and function in cells that are involved in physiologic responses and contribute to human pathophysiology.

Professor Insel’s lab has recently discovered roles for previously unappreciated GPCRs, including orphan GPCRs, in a variety of cell types, including GPCRs that likely contribute to cardiovascular disease and numerous types of cancer. The results provide opportunities for new therapies in several disease settings, including pancreatic cancer and others, for which new, effective therapeutic approaches are an important, unmet medical need.

For more information, please contact Professor Debbie Hay.